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Số người truy cập: 109,889,959

 Simultaneous electrochemical determination of uric acid and hypoxanthine at a TiO2/graphene quantum dot-modified electrode
Tác giả hoặc Nhóm tác giả: Vu Ngoc Hoang1,2, Dang Thi Ngoc Hoa3 , Nguyen Quang Man3 , Le Vu Truong Son4 , Le Van Thanh Son4 , Vo Thang Nguyen4 , Le Thi Hong Phong5 , Ly Hoang Diem6 , Kieu Chan Ly7 , Ho Sy Thang*7 and Dinh Quang Khieu*1
Nơi đăng: Beilstein J. Nanotechno; Số: 15;Từ->đến trang: 719–732;Năm: 2024
Lĩnh vực: Khoa học công nghệ; Loại: Bài báo khoa học; Thể loại: Quốc tế
TÓM TẮT
A TiO2 /graphene quantum dots composite (TiO2 /GQDs) obtained by in situ synthesis of GQDs, derived from coffee grounds, and peroxo titanium complexes was used as electrode modifier in the simultaneous electrochemical determination of uric acid and hypoxanthine. The TiO2 /GQDs material was characterized by photoluminescence, X-ray diffraction, Raman spectroscopy, highresolution transmission electron microscopy, and energy-dispersive X-ray mapping. The TiO2 /GQDs-GCE exhibits better electrochemical activity for uric acid and hypoxanthine than GQDs/GCE or TiO2 /GCE in differential pulse voltammetry (DPV) measurements. Under optimized conditions, the calibration plots were linear in the range from 1.00 to 15.26 μM for both uric acid and hypoxanthine. The limits of detection of this method were 0.58 and 0.68 μM for uric acid and hypoxanthine, respectively. The proposed DPV method was employed to determine uric acid and hypoxanthine in urine samples with acceptable recovery rates.
ABSTRACT
A TiO2 /graphene quantum dots composite (TiO2 /GQDs) obtained by in situ synthesis of GQDs, derived from coffee grounds, and peroxo titanium complexes was used as electrode modifier in the simultaneous electrochemical determination of uric acid and hypoxanthine. The TiO2 /GQDs material was characterized by photoluminescence, X-ray diffraction, Raman spectroscopy, highresolution transmission electron microscopy, and energy-dispersive X-ray mapping. The TiO2 /GQDs-GCE exhibits better electrochemical activity for uric acid and hypoxanthine than GQDs/GCE or TiO2 /GCE in differential pulse voltammetry (DPV) measurements. Under optimized conditions, the calibration plots were linear in the range from 1.00 to 15.26 μM for both uric acid and hypoxanthine. The limits of detection of this method were 0.58 and 0.68 μM for uric acid and hypoxanthine, respectively. The proposed DPV method was employed to determine uric acid and hypoxanthine in urine samples with acceptable recovery rates.
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