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Số người truy cập: 107,030,593

 Mechanistic and kinetic studies of the radical scavenging activity of natural abietanes: A theoretical insight (SCIE)
Tác giả hoặc Nhóm tác giả: Nguyen Minh Tam, Nguyen Minh Thong, Nguyen Thi Hoa, Loc Phuoc Hoang, Pham Cam Nam, Duong Tuan Quang, Adam Mechler, Quan V Vo
Nơi đăng: Chemical Physics Letters; Số: 777;Từ->đến trang: 138737;Năm: 2021
Lĩnh vực: Tự nhiên; Loại: Bài báo khoa học; Thể loại: Quốc tế
TÓM TẮT
Abietanes are natural products that were isolated from Salvia clinopodioides. In this work, the HOOradical dot scavenging activity of ten abietanes was thoroughly evaluated by using computational methods for the first time. It was found that the studied abietanes could exhibit moderate HOOradical dot scavenging activity. Considerable antioxidant activity of the abietanes was only predicted in the aqueous solution and not in lipidic environments. Among the studied compounds, aldehyde (10) exhibited the highest HOOradical dot radical scavenging activity in the aqueous solution (koverall = 3.72 × 108 M−1s−1) that is higher than the reference natural antioxidants Trolox, trans-resveratrol, and ascorbic acid.
ABSTRACT
Abietanes are natural products that were isolated from Salvia clinopodioides. In this work, the HOOradical dot scavenging activity of ten abietanes was thoroughly evaluated by using computational methods for the first time. It was found that the studied abietanes could exhibit moderate HOOradical dot scavenging activity. Considerable antioxidant activity of the abietanes was only predicted in the aqueous solution and not in lipidic environments. Among the studied compounds, aldehyde (10) exhibited the highest HOOradical dot radical scavenging activity in the aqueous solution (koverall = 3.72 × 108 M−1s−1) that is higher than the reference natural antioxidants Trolox, trans-resveratrol, and ascorbic acid.
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