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 Is Indolinonic Hydroxylamine a Promising Artificial Antioxidant?
Tác giả hoặc Nhóm tác giả: Quan V Vo, Mai Van Bay, Pham Cam Nam, Adam Mechler
Nơi đăng: The Journal of Physical Chemistry B; Số: 123(37);Từ->đến trang: 7777-7784;Năm: 2019
Lĩnh vực: Tự nhiên; Loại: Bài báo khoa học; Thể loại: Quốc tế
TÓM TẮT
Indolinonic hydroxylamine (IH) is a new-generation artificial antioxidant that, due to its ability to fractionate into apolar environments, is considered for prevention against lipid peroxidation. For this reason, it is important to understand, and compare, its activity in polar and nonpolar environments. In this study, the antioxidant activity of IH has been evaluated against HO• and HOO• radicals in water and, for a lipid-mimetic environment, pentyl ethanoate solvent, using kinetic calculations. It was found that the overall reaction rate constant of the HO• radical scavenging is more than 7 times higher in aqueous (8.98 × 109 M–1 s–1) than in apolar (1.22 × 109 M–1 s–1) media. However, HOO• scavenging was 35 times faster in apolar media (1.00 × 105 M–1 s–1 vs 2.80 × 103 M–1 s–1). In a lipid environment, the HAT mechanism was favored for the antioxidant activity for both radical species, whereas in aqueous solution the …
ABSTRACT
Indolinonic hydroxylamine (IH) is a new-generation artificial antioxidant that, due to its ability to fractionate into apolar environments, is considered for prevention against lipid peroxidation. For this reason, it is important to understand, and compare, its activity in polar and nonpolar environments. In this study, the antioxidant activity of IH has been evaluated against HO• and HOO• radicals in water and, for a lipid-mimetic environment, pentyl ethanoate solvent, using kinetic calculations. It was found that the overall reaction rate constant of the HO• radical scavenging is more than 7 times higher in aqueous (8.98 × 109 M–1 s–1) than in apolar (1.22 × 109 M–1 s–1) media. However, HOO• scavenging was 35 times faster in apolar media (1.00 × 105 M–1 s–1 vs 2.80 × 103 M–1 s–1). In a lipid environment, the HAT mechanism was favored for the antioxidant activity for both radical species, whereas in aqueous solution the …
[ https://pubs.acs.org/doi/abs/10.1021/acs.jpcb.9b05160 ]
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