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Số người truy cập: 107,389,860

 The mechanistic and kinetic study of the radical scavenging activity of natural abietanes: a theoretical insight
Tác giả hoặc Nhóm tác giả: Nguyen Minh Tam, Nguyen Minh Thong, Nguyen Thi Hoa, Loc Phuoc Hoang, Pham Cam Nam, Duong Tuan Quang, Adam Mechler, Quan V Vo
Nơi đăng: Chemical Physics letters; Số: 777;Từ->đến trang: 138737-138742;Năm: 2021
Lĩnh vực: Chưa xác định; Loại: Bài báo khoa học; Thể loại: Quốc tế
TÓM TẮT
Abietanes are natural products that were isolated from Salvia clinopodioides. In this work, the HOO• antiradical activity of ten abietanes was thoroughly evaluated by using computational methods for the first time. It was found that the studied abietanes could exhibit moderate HOO• antiradical activity. Considerable antioxidant activity of the abietanes is only predicted in an aqueous solution and not in lipidic environments. Among the studied compounds, aldehyde (10) exhibited the highest HOO• radical scavenging activity in the aqueous solution (koverall = 3.72×108 M−1s−1) that is higher than the reference natural antioxidants Trolox, trans-resveratrol, and ascorbic acid.
ABSTRACT
Abietanes are natural products that were isolated from Salvia clinopodioides. In this work, the HOO• antiradical activity of ten abietanes was thoroughly evaluated by using computational methods for the first time. It was found that the studied abietanes could exhibit moderate HOO• antiradical activity. Considerable antioxidant activity of the abietanes is only predicted in an aqueous solution and not in lipidic environments. Among the studied compounds, aldehyde (10) exhibited the highest HOO• radical scavenging activity in the aqueous solution (koverall = 3.72×108 M−1s−1) that is higher than the reference natural antioxidants Trolox, trans-resveratrol, and ascorbic acid.
[ https://www.sciencedirect.com/science/article/abs/pii/S0009261421004206 ]
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