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 Preparation and crystal structure of sorafenib sulfate monohydrate
Tác giả hoặc Nhóm tác giả: Chi Uyen Phan; Ngoc Bich Huynh; Hong Son Nguyen; Thi Ngoc Hang Do
Nơi đăng: 2020 Applying New Technology in Green Buildings (ATiGB); Số: 978-1-7281-8658-0;Từ->đến trang: 65-69;Năm: 2021
Lĩnh vực: Y - Dược; Loại: Bài báo khoa học; Thể loại: Quốc tế
TÓM TẮT
Salt formation is the most commonly method for increasing the solubility of drug. Sorafenib (Sor), a multikinase inhibitor active in the treatment a board of human cancers, has a very low solubility. In this study, sorafenib sulfate monohydrate (Sor-S) has been prepared for improving its solubility. The simulated powder X-ray diffraction (PXRD) was different from experimental PXRD of free Sor. The crystal structure of Sor-S was characterized. The hydrogen bond system, topology, and the superposition of the molecular conformations of sorafenib in base form and protonated cation in salt form were analyzed. The Hirshfeld surfaces plotted with dnorm was conducted for investigating the hydrogen bonds. Shape index and curvedness maps presented two rings with π π interplanar stacking. The tabletability was predicted using an energy framework.
ABSTRACT
Salt formation is the most commonly method for increasing the solubility of drug. Sorafenib (Sor), a multikinase inhibitor active in the treatment a board of human cancers, has a very low solubility. In this study, sorafenib sulfate monohydrate (Sor-S) has been prepared for improving its solubility. The simulated powder X-ray diffraction (PXRD) was different from experimental PXRD of free Sor. The crystal structure of Sor-S was characterized. The hydrogen bond system, topology, and the superposition of the molecular conformations of sorafenib in base form and protonated cation in salt form were analyzed. The Hirshfeld surfaces plotted with dnorm was conducted for investigating the hydrogen bonds. Shape index and curvedness maps presented two rings with π π interplanar stacking. The tabletability was predicted using an energy framework.
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