Thông tin chung
  English
  Đề tài NC khoa học
  Bài báo, báo cáo khoa học
  Hướng dẫn Sau đại học
  Sách và giáo trình
  Các học phần và môn giảng dạy
  Giải thưởng khoa học, Phát minh, sáng chế
  Khen thưởng
  Thông tin khác
  Tài liệu tham khảo
  Hiệu chỉnh
 
Số người truy cập: 109,900,302

 Cytotoxic Activity of Compounds from Vietnamese Goniothalamus elegans Ast.
Tác giả hoặc Nhóm tác giả: Tran, L. T. T., Nguyen, T. K., To, D. C., Pham, P. T., Tran, M. H., & Nguyen, T. T.
Nơi đăng: Tropical Journal of Natural Product Research; Số: 7(7);Từ->đến trang: 3496-3501;Năm: 2023
Lĩnh vực: Y - Dược; Loại: Bài báo khoa học; Thể loại: Quốc tế
TÓM TẮT
Goniothalamus elegans Ast is a plant commonly used in traditional medicine for the treatment of heart disease and diarrhea. Although there has been one published study on its chemical composition, limited research has been conducted on its bioactivity. In this study, the aerial part of G. elegans was extracted using the soaking method and further subjected to column chromatography for isolation. The isolated compounds were then evaluated for cytotoxicity using SRB staining. From the aerial part of G. elegans, four compounds were successfully isolated and identified as (23R)-21,23-epoxy-5a-cycloart-24-en-3ß-ol (1), stigmasterol (2), aristolactam BII
(3), and piperolactam C (4). Among these compounds, aristolactam BII and piperolactam C exhibited moderate cytotoxicity against SW-489, AGS, LU-1, and HepG2 cell lines, with IC50 values ranging from 55.55 to 96.21 µg/mL. This study reveals that the phytochemical composition of G. elegans and demonstrates its potential cytotoxic activity, indicating promising avenues for
further exploration in future research endeavors.
ABSTRACT
Goniothalamus elegans Ast is a plant commonly used in traditional medicine for the treatment of heart disease and diarrhea. Although there has been one published study on its chemical composition, limited research has been conducted on its bioactivity. In this study, the aerial part of G. elegans was extracted using the soaking method and further subjected to column chromatography for isolation. The isolated compounds were then evaluated for cytotoxicity using SRB staining. From the aerial part of G. elegans, four compounds were successfully isolated and identified as (23R)-21,23-epoxy-5a-cycloart-24-en-3ß-ol (1), stigmasterol (2), aristolactam BII
(3), and piperolactam C (4). Among these compounds, aristolactam BII and piperolactam C exhibited moderate cytotoxicity against SW-489, AGS, LU-1, and HepG2 cell lines, with IC50 values ranging from 55.55 to 96.21 µg/mL. This study reveals that the phytochemical composition of G. elegans and demonstrates its potential cytotoxic activity, indicating promising avenues for
further exploration in future research endeavors.
© Đại học Đà Nẵng
 
 
Địa chỉ: 41 Lê Duẩn Thành phố Đà Nẵng
Điện thoại: (84) 0236 3822 041 ; Email: dhdn@ac.udn.vn