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Số người truy cập: 109,900,393
Whole-genome analysis and secondary metabolites production of a new strain
Brevibacillus halotolerans
7WMA2: A potential biocontrol agent against fungal pathogens
Tác giả hoặc Nhóm tác giả:
Ho Le Han, Lingmin Jiang, Thi Ngoc Thu Tran, Neak Muhammad, Song-Gun Kim,
Vinh Phu Tran Pham
, Yan Jer Ng, Kuan Shiong Khoo, Kit Wayne Chew, Thi Dong Phuong Nguyen
Nơi đăng:
Chemosphere - ScienceDirect;
S
ố:
307(4);
Từ->đến trang
: 136004;
Năm:
2022
Lĩnh vực:
Khoa học công nghệ;
Loại:
Bài báo khoa học;
Thể loại:
Quốc tế
TÓM TẮT
The extensive usage of synthetic fungicides against fungal diseases has caused adverse impacts on both human and agricultural crops. Therefore, the current study aims to establish a new bacterium 7WMA2, as a biocontrol agent to achieve better antifungal results. The strain 7WMA2 was isolated from marine sediment, displayed a broad spectrum of several fungi that includes
Alternaria alternata
,
Cladosporium
sp.,
Candida albicans
,
Fusarium oxysporum
,
Trichosporon pullulans
, and
Trichophyton rubrum
. The 16S rRNA phylogeny inferred that strain 7WMA2 was a member of
Brevibacillus
. The phylogenetic and biochemical analyses revealed that the strain 7WMA2 belongs to the species of
Brevibacillus halotolerans
. The complete genome sequence of
Brevibacillus halotolerans
7WMA2 consists of a circular chromosome of 5,351,077 bp length with a GC content of 41.39 mol %, including 4433 CDS, 111 tRNA genes, and 36 rRNA genes. The genomic analysis showed 23 putative biosynthetic secondary metabolite gene clusters responsible for non-ribosomal peptides, polyketides and siderophores. The antifungal compounds concentrated from cell-free fermentation broth demonstrated strong inhibition of fungi, and the compounds are considerably thermal stable and adaptable to pH range 2–12. This complete genome sequence has provided insight for further exploration of antagonistic ability and its secondary metabolite compounds indicated feasibility as biological control agents against fungal infections.
ABSTRACT
The extensive usage of synthetic fungicides against fungal diseases has caused adverse impacts on both human and agricultural crops. Therefore, the current study aims to establish a new bacterium 7WMA2, as a biocontrol agent to achieve better antifungal results. The strain 7WMA2 was isolated from marine sediment, displayed a broad spectrum of several fungi that includes
Alternaria alternata
,
Cladosporium
sp.,
Candida albicans
,
Fusarium oxysporum
,
Trichosporon pullulans
, and
Trichophyton rubrum
. The 16S rRNA phylogeny inferred that strain 7WMA2 was a member of
Brevibacillus
. The phylogenetic and biochemical analyses revealed that the strain 7WMA2 belongs to the species of
Brevibacillus halotolerans
. The complete genome sequence of
Brevibacillus halotolerans
7WMA2 consists of a circular chromosome of 5,351,077 bp length with a GC content of 41.39 mol %, including 4433 CDS, 111 tRNA genes, and 36 rRNA genes. The genomic analysis showed 23 putative biosynthetic secondary metabolite gene clusters responsible for non-ribosomal peptides, polyketides and siderophores. The antifungal compounds concentrated from cell-free fermentation broth demonstrated strong inhibition of fungi, and the compounds are considerably thermal stable and adaptable to pH range 2–12. This complete genome sequence has provided insight for further exploration of antagonistic ability and its secondary metabolite compounds indicated feasibility as biological control agents against fungal infections.
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