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 Regioselective Synthesis of Cellulose Carbamate-Based Chiral Cation Exchangers for Enantiomer Resolution by HPLC
Tác giả hoặc Nhóm tác giả: Cuong Viet BUI, Ivan MELIKHOV, Wolfgang LINDNER, Thomas ROSENAU, and Hubert HETTEGGER
Nơi đăng: 7th International Polysaccharide Conference of EPNOE; Số: None;Từ->đến trang: None;Năm: 2021
Lĩnh vực: Khoa học; Loại: Báo cáo; Thể loại: Quốc tế
TÓM TẮT
Chirality is one of the fundamental features in the structure and chemistry of all living organisms. The chemistry of dead and living matters is defined by asymmetric characteristics of naturally occurring organic compounds in terms of enantiomers which exhibit different properties in biochemical systems, as already recognized more than 150 years ago.1 High performance liquid chromatography (HPLC) equipped with chiral stationary phases is one of the most powerful methods to separate enantiomers.2 Because of their high enantiomer separation power, cellulose and cellulose derivatives have been exploited and used as chiral selectors in our work. Regioselective synthesis was employed to modify cellulose to bear different substituents at C2, C3, and C6 as the respective chiral selectors. The cellulose derivatives were comprehensively characterized by ATR-FTIR, solid- and liquid-state NMR, GPC. The degrees of substitution were analyzed or monitored by elemental analysis, UV/Vis spectrometry, and thin-layer chromatography. Azidopropyl functionalized silica gel was employed as an inert carrier to immobilize cellulose derivatives by “click chemistry”. The selector loading on silica gel was inter alia analyzed by TGA. The chiral stationary phase materials were packed into stainless steel columns and their enantiomer separation performance evaluated by HPLC with a set of target analytes and compared to commercially available chiral stationary phases.
ABSTRACT
[ 2022\2022m01d02_16_38_44Poster_EPNOE_CVB_final.pdf ]
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