Thông tin chung
  English
  Đề tài NC khoa học
  Bài báo, báo cáo khoa học
  Hướng dẫn Sau đại học
  Sách và giáo trình
  Các học phần và môn giảng dạy
  Giải thưởng khoa học, Phát minh, sáng chế
  Khen thưởng
  Thông tin khác
  Tài liệu tham khảo
  Hiệu chỉnh
 
Số người truy cập: 106,856,697

 Cross-linked Thermo-Responsive Polymeric Vesicles as Doxorubicin Delivery Carriers
marriage affairs all wife cheat i want an affair
cvs weekly sale cvs print prescription savings cards
Tác giả hoặc Nhóm tác giả: Viet Thang Ho, Wen-Hsuan Chiang, Hsin-Cheng Chiu
Nơi đăng: Proceedings of The 6th Taiwan-Japan and 1st Asia International Symposium on Chemical-Environment-Biomedical Technology
marriage affairs blog.ivanovtech.com i want an affair
; Số: 6;Từ->đến trang: 39;Năm: 2011
Lĩnh vực: Kỹ thuật; Loại: Bài báo khoa học; Thể loại: Quốc tế
TÓM TẮT
ABSTRACT
Polymer vesicles were co-assembed from well dissolved solution of two graft copolymers both comprising acrylic acid (AAc) and 2-methacryloylethyl acrylate (MEA) units as the backbone and either poly(N-isopropylacrylamide) (PNIPAAm) alone or PNIPAAm or both PNIPAAm and monomethoxypoly(ethylene glycol) (mPEG) chain segments as the grafts via hydrogen bonding of unionized AAc with NIPAAm moieties with medium pH being lowered from 7.4 to 3.0 at 25oC.1 The PAAc/PNIPAAm-rich hydrophobic membranes of vesicles were further cross-linked upon radical polymerization of the MEA units.2 The cross-linked (CL) vesicles exhibited fully reversible structural regulations in response to changes in pH and temperature. In addition, doxorubicin (DOX) frequently used in cancer chemotherapy was encapsulated into CL vesicles via complementary electrostatic interactions of DOX molecules with ionized AAc residues.3 The DOX-loaded CL vesicles at pH 5.0 showed a rapid drug release profile compare to those at pH 7.4 as a results of extensive disruption of electrostatic interaction between the drug molecules and the AAc moieties. Such as pH-triggered DOX release is strongly desirable for controlled intracellular release of the anticancer agent within endosomal and lysosomal compartments
© Đại học Đà Nẵng
 
 
Địa chỉ: 41 Lê Duẩn Thành phố Đà Nẵng
Điện thoại: (84) 0236 3822 041 ; Email: dhdn@ac.udn.vn