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Số người truy cập: 106,081,003

 Nano-Scaled Polymeric Vesicles with Temperature- and pH-Sensitive Cross-Linked membranes as Doxorubicin Delivery Carriers
Tác giả hoặc Nhóm tác giả: Viet Thang Ho, Wen-Hsuan Chiang, Hsin-Cheng Chiu
Nơi đăng: Proceedings of Annual Meeting of the Polymer Society, Taipei, Taiwan; Số: 2012;Từ->đến trang: 125;Năm: 2012
Lĩnh vực: Khoa học; Loại: Bài báo khoa học; Thể loại: Quốc tế
TÓM TẮT

ABSTRACT
In this work, polymeric vesicles were co-assembed from well dissolved solution of two graft copolymers both comprising acrylic acid (AAc) and 2-methacryloylethyl acrylate (MEA) units as the backbone and either poly(N-isopropylacrylamide) (PNIPAAm) alone (copolymer A) or both PNIPAAm and monomethoxypoly(ethylene glycol) (mPEG) chain segments as the grafts (copolymer B) via hydrogen bonding of unionized AAc with NIPAAm moieties with medium pH being lowered from 7.4 to 3.0 at 25oC. The PAAc/PNIPAAm-rich hydrophobic membranes of vesicles were further cross-linked upon radical polymerization of the MEA units. The cross-linked (CL) vesicles exhibited fully reversible structural regulations in response to changes in pH and temperature. In addition, doxorubicin (DOX) frequently used in cancer chemotherapy was encapsulated into CL polymeric vesicles via complementary electrostatic interactions of DOX molecules with ionized AAc residues. The DOX-loaded CL polymeric vesicles at pH 5.0 showed a rapid drug release profile compare to those at pH 6.0 and 7.4 as a results of extensive disruption of electrostatic interaction between the drug molecules and the AAc moieties. Furthermore, cytotoxicity of DOX-loaded CL polymeric vesicles on Hela cell exhibit similar to free DOX. Therefore, such polymeric vesicles with pH- and thermo-responsive CL membranes show great potentiality of effective DOX delivery carrier
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