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 Preparation of Iron Oxide Nanoparticles-Loaded Polymersomes for Drug-Targeting DeliverySystem and Magnetic Resonance Imaging (MRI)
Tác giả hoặc Nhóm tác giả: Viet Thang Ho, Nguyen Thi Minh Xuan, Wen-Hsuan Chiang, Hsin-Cheng Chiu
Nơi đăng: Journal of Science and Technology, The University of Danang; Số: 12 (61) Vol 1;Từ->đến trang: 16-23;Năm: 2012
Lĩnh vực: Y - Dược; Loại: Bài báo khoa học; Thể loại: Trong nước
TÓM TẮT
In this research, we develop Iron oxide nanoparticles-loaded polymeric assemblies through co-association of citric acid-modified iron oxide nanoparticles (IONPs) with graft copolymer consisting of acrylic acid (AAc) and 2-methacryloylethyl acrylate (MEA) units as the backbone and both poly(N-isopropylacrylamide) (PNIPAAm) and monomethoxypoly(ethylene glycol) (mPEG) as the grafts. IONPs were caged into polymersome via extensive hydrogen bonding of unionized carboxyl acid and NIPAAm residues with medium pH being adjusted from pH 7.4 to pH 3.0, the IONPs-loaded polymersomes (IONPs-P) were attained and then cross-linked upon photo-initiated radical polymerization of the MEA units. The obtained cross-linked (CL) IONPs-P have a particles size of ca. 200 nm in diameter and superparamagnetic properties. Moreover, being internalized by HeLa cells via endocytosis, the CL IONPs-P still showed significantly dark images. The results illustrate their potential applications as a theranostic platform
ABSTRACT
In this research, we develop Iron oxide nanoparticles-loaded polymeric assemblies through co-association of citric acid-modified iron oxide nanoparticles (IONPs) with graft copolymer consisting of acrylic acid (AAc) and 2-methacryloylethyl acrylate (MEA) units as the backbone and both poly(N-isopropylacrylamide) (PNIPAAm) and monomethoxypoly(ethylene glycol) (mPEG) as the grafts. IONPs were caged into polymersome via extensive hydrogen bonding of unionized carboxyl acid and NIPAAm residues with medium pH being adjusted from pH 7.4 to pH 3.0, the IONPs-loaded polymersomes (IONPs-P) were attained and then cross-linked upon photo-initiated radical polymerization of the MEA units. The obtained cross-linked (CL) IONPs-P have a particles size of ca. 200 nm in diameter and superparamagnetic properties. Moreover, being internalized by HeLa cells via endocytosis, the CL IONPs-P still showed significantly dark images. The results illustrate their potential applications as a theranostic platform
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