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Số người truy cập: 109,418,344

 THE CYTOTOXIC ACTIVITY OF LIGNANS AND MONOTERPENOIDS FROM
THE MALE CARICA PAPAYA FLOWERS ON A549 LUNG CANCER, HEP3B
LIVER CANCER, AND MCF-7 BREAST CANCER CELL LINES
Tác giả hoặc Nhóm tác giả: Do Thi Thuy Van
Nơi đăng: THE UNIVERSITY OF DANANG - JOURNAL OF SCIENCE AND TECHNOLOGY; Số: VOL. 21, NO. 12.1, 2023;Từ->đến trang: 117-122;Năm: 2023
Lĩnh vực: Tự nhiên; Loại: Bài báo khoa học; Thể loại: Trong nước
TÓM TẮT
Two lignans (lariciresinol (1) and dehydrodiconiferyl
alcohol (2)), and four monoterpenoids (vitexoid (3), 6-hydroxy-
2,6-dimethyl-2,7-octadienoic acid (4), 6-hydroxy-2,6-
dimethyloct-7-enoic acid (5), 2,6-dimethylocta-2,7-diene-1,6-
diol (6)) from the male Carica papaya flowers are conducted a
cytotoxic activity for lung cancer cells (A549), liver cancer cells
(Hep3B), and breast cancer cells (MCF-7). The results, lignan
(1), and monoterpenoid (3), (6) exhibited medium cytotoxic
activity on these cancer cells with IC50 from 34.73±1.55 to
66.12±5.60 µg/mL. Lignan (2) displayed medium cytotoxic
activity on MCF-7, Hep3B with IC50 60.85±4.43, 62.32±
5.03 µg/mL, respectively, and weak cytotoxic activity on A549
with IC50 70.99±7.26 µg/mL. Monoterpenoids (4), and (5)
showed medium cytotoxic activity on MCF-7 with IC50
54.15±5.89, 67.49±2.41 µg/mL, respectively, and weak
cytotoxic activity on A549, and Hep3B with IC50 from
72.25±3.13 to 86.03±7.57 µg/mL. Ellipticine was a positive
control.
ABSTRACT
Two lignans (lariciresinol (1) and dehydrodiconiferyl
alcohol (2)), and four monoterpenoids (vitexoid (3), 6-hydroxy-
2,6-dimethyl-2,7-octadienoic acid (4), 6-hydroxy-2,6-
dimethyloct-7-enoic acid (5), 2,6-dimethylocta-2,7-diene-1,6-
diol (6)) from the male Carica papaya flowers are conducted a
cytotoxic activity for lung cancer cells (A549), liver cancer cells
(Hep3B), and breast cancer cells (MCF-7). The results, lignan
(1), and monoterpenoid (3), (6) exhibited medium cytotoxic
activity on these cancer cells with IC50 from 34.73±1.55 to
66.12±5.60 µg/mL. Lignan (2) displayed medium cytotoxic
activity on MCF-7, Hep3B with IC50 60.85±4.43, 62.32±
5.03 µg/mL, respectively, and weak cytotoxic activity on A549
with IC50 70.99±7.26 µg/mL. Monoterpenoids (4), and (5)
showed medium cytotoxic activity on MCF-7 with IC50
54.15±5.89, 67.49±2.41 µg/mL, respectively, and weak
cytotoxic activity on A549, and Hep3B with IC50 from
72.25±3.13 to 86.03±7.57 µg/mL. Ellipticine was a positive
control.
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