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Số người truy cập: 106,824,649

 A thermodynamic and kinetic study of the antioxidant activity of natural hydroanthraquinones (SCIE)
Tác giả hoặc Nhóm tác giả: Quan V. Vo1*, Nguyen Minh Thong3*, Trinh Le Huyen4, Pham Cam Nam5, Nguyen Minh Tam6,7* Nguyen Thi Hoa8 and Adam Mechler9
Nơi đăng: RSC Advances; Số: 10;Từ->đến trang: 20089–20097;Năm: 2020
Lĩnh vực: Tự nhiên; Loại: Bài báo khoa học; Thể loại: Quốc tế
TÓM TẮT
Novel hydroanthraquinones isolated from marine algal-derived endophytic fungus Talaromyces Islandicus EN-501 exhibited promising antioxidant properties in preliminary studies, raising the prospect of adapting these compounds for therapeutic use in diseases caused by oxidative stress. For medicinal applications it is beneficial to develop a full understanding of the antioxidant activity of these compounds. In this study, the hydroperoxide radical scavenging activity of five natural hydroanthraquinones was evaluated by kinetic and thermodynamic calculations. The results showed that the radical scavenging of these hydroanthraquinones in the gas phase and in lipid solvents was defined by the formal hydrogen transfer mechanism, that for the polar environments was decided by the sequential proton loss electron transfer pathway. The hydroanthraquinones exhibited good hydroperoxide scavenging activity in both polar and non-polar media. The overall rate constant values for the radical scavenging reaction were in the range of 3.42´101 to 2.60´105 M-1s-1and 3.80´106 to 5.87´107 M-1s-1 in pentyl ethanoate and water solvents, respectively. Thus the activity of 8-hydroxyconiothyrinone B (1) is about 2.6 and 444.6 times higher than that of Trolox in the studied solvents, identifying 8-hydroxyconiothyrinone B as a promising antioxidant
ABSTRACT
Novel hydroanthraquinones isolated from marine algal-derived endophytic fungus Talaromyces Islandicus EN-501 exhibited promising antioxidant properties in preliminary studies, raising the prospect of adapting these compounds for therapeutic use in diseases caused by oxidative stress. For medicinal applications it is beneficial to develop a full understanding of the antioxidant activity of these compounds. In this study, the hydroperoxide radical scavenging activity of five natural hydroanthraquinones was evaluated by kinetic and thermodynamic calculations. The results showed that the radical scavenging of these hydroanthraquinones in the gas phase and in lipid solvents was defined by the formal hydrogen transfer mechanism, that for the polar environments was decided by the sequential proton loss electron transfer pathway. The hydroanthraquinones exhibited good hydroperoxide scavenging activity in both polar and non-polar media. The overall rate constant values for the radical scavenging reaction were in the range of 3.42´101 to 2.60´105 M-1s-1and 3.80´106 to 5.87´107 M-1s-1 in pentyl ethanoate and water solvents, respectively. Thus the activity of 8-hydroxyconiothyrinone B (1) is about 2.6 and 444.6 times higher than that of Trolox in the studied solvents, identifying 8-hydroxyconiothyrinone B as a promising antioxidant
[ 2020\2020m06d022_8_4_31authorreprints.pdf ]
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