Thông tin chung
  English
  Đề tài NC khoa học
  Bài báo, báo cáo khoa học
  Hướng dẫn Sau đại học
  Sách và giáo trình
  Các học phần và môn giảng dạy
  Giải thưởng khoa học, Phát minh, sáng chế
  Khen thưởng
  Thông tin khác
  Tài liệu tham khảo
  Hiệu chỉnh
 
Số người truy cập: 107,313,238

 Green synthesis of silver nanoparticles using callisia fragrans leaf extract and its anticancer activity against MCF7, HepG2, KB, Lu-1 and MKN-7 cell lines
Tác giả hoặc Nhóm tác giả: Hai Tu Le, Lan Anh Thi Nguyen, Bay Van Mai, Din Van Nguyen, Ngoc Quyen Thi Nguyen, Vuogn Van Pham
Nơi đăng: Journal of Green Processing and Synthesis; Số: Vol. 12, No. 1;Từ->đến trang: 1-17;Năm: 2023
Lĩnh vực: Khoa học; Loại: Bài báo khoa học; Thể loại: Quốc tế
TÓM TẮT
ABSTRACT
This article presents a simple, eco-friendly, and
green method for the synthesis of silver nanoparticles
(AgNPs) from AgNO3 solution utilizing an aqueous extract
of Callisia fragrans leaf. The effects of C. fragrans leaf
extraction conditions were evaluated. Parameters affecting
the synthesis of AgNPs, such as the volume of extract, pH,
temperature, and reaction time were investigated and optimized. The obtained AgNPs were analyzed by UV–Vis
spectroscopy, X-ray diffraction pattern, energy-dispersive
X-ray spectroscopy, field emission scanning electron microscopy, transmission electron microscopy (TEM), dynamic
light scattering (DLS), and FTIR techniques. TEM and DLS
analyses have shown that the synthesized AgNPs were predominantly spherical in shape with an average size of 48 nm.
The zeta potential of the colloidal solution of AgNPs is
-27 mV, indicating the dispersion ability of AgNPs. The
results of GC–MS and FTIR analyses show the presence of
biomolecules in the aqueous extract of C. fragrans leaf that
acts as reducing and capping agents for the biosynthesis
of AgNPs. The synthesized AgNPs demonstrate anticancer
activity against MCF-7, HepG2, KB, LU-1, and MKN-7 cell
lines, with inhibitory concentrations at 50% (IC50 values) of
2.41, 2.31, 2.65, 3.26, and 2.40 µg·mL-1, respectively. The
obtained results in the study show that the biosynthesized AgNP from C. fragrans leaf extract can be further exploited as
a potential candidate for anticancer agents.

© Đại học Đà Nẵng
 
 
Địa chỉ: 41 Lê Duẩn Thành phố Đà Nẵng
Điện thoại: (84) 0236 3822 041 ; Email: dhdn@ac.udn.vn