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 Oxoberberine: a promising natural antioxidant in physiological environments
Tác giả hoặc Nhóm tác giả: Adam Mechler and Quan V. Vo Pham Cam Nam, a Nguyen Quang Trung, Nguyen Thi Hoa,Huynh Ngoc Bich,Tran Duc Manh,Duong Tuan Quang
Nơi đăng: RSC Advances; Số: 12;Từ->đến trang: 9738;Năm: 2022
Lĩnh vực: Tự nhiên; Loại: Bài báo khoa học; Thể loại: Quốc tế
TÓM TẮT
Oxoberberine (OB, 2,10-dihydroxy-3,9-dimethoxy-8-oxo-protoberberine, artathomsonine), which was isolated from Artabotrys thomsonii, was shown to exhibit potent antioxidant activity in vitro, however that is the only reported evidence of the radical scavenging activity of this compound thus far. In the present study, thermodynamic and kinetic calculations were used to determine the free radical scavenging activity of OB against a range of biologically important species, under physiological conditions. In the first part the activity is calculated against the HOO˙ radical that is both biologically important and a reference radical for comparison. It was found that OB has high antiradical capacity against HOO˙ in both lipid medium and water at physiological pH with koverall = 1.33 × 105 and 1.73 × 106 M−1 s−1, respectively. The formal hydrogen transfer mechanism defined the activity in nonpolar environments, whereas in …
ABSTRACT
Oxoberberine (OB, 2,10-dihydroxy-3,9-dimethoxy-8-oxo-protoberberine, artathomsonine), which was isolated from Artabotrys thomsonii, was shown to exhibit potent antioxidant activity in vitro, however that is the only reported evidence of the radical scavenging activity of this compound thus far. In the present study, thermodynamic and kinetic calculations were used to determine the free radical scavenging activity of OB against a range of biologically important species, under physiological conditions. In the first part the activity is calculated against the HOO˙ radical that is both biologically important and a reference radical for comparison. It was found that OB has high antiradical capacity against HOO˙ in both lipid medium and water at physiological pH with koverall = 1.33 × 105 and 1.73 × 106 M−1 s−1, respectively. The formal hydrogen transfer mechanism defined the activity in nonpolar environments, whereas in …
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