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 Anti-cholinesterases and memory improving effects of Vietnamese Xylia xylocarpa
Tác giả hoặc Nhóm tác giả: Linh My Thi Lam,Mai Thanh Thi Nguyenmail author,Hai Xuan Nguyen,Phu Hoang Dang,Nhan Trung Nguyen,Hung Manh Tran,Hoa Thi Nguyen,Nui Minh Nguyen,Byung Sun Min,Jeong Ah Kim,Jae Sue Choi andMao Van Can
Nơi đăng: Chemistry Central Journal; Số: DOI: 10.1186/s13065-016-0197-5;Từ->đến trang: 10.1186/s13065-016-0197-5;Năm: 2016
Lĩnh vực: Y - Dược; Loại: Bài báo khoa học; Thể loại: Quốc tế
TÓM TẮT
BackgroundAlzheimer’s disease (AD) is the most common cause of dementia among the elderly and is characterized by loss of memory and other cognitive functions. An increase in AChE (a key enzyme in the cholinergic nervous system) levels around β-amyloid plaques and neurofibrillary tangles is a common feature of AD neuropathology. Amnesic effects of scopolamine (acetylcholine receptor antagonist) can be investigated in various behavioral tests such as Morris water maze, object recognition, Y-maze, and passive avoidance. In the scope of this paper, we report the anti-AChE, anti-BChE properties of the isolated compound and the in vivo effects of the methanolic extract ofXylia xylocarpa (MEXX) on scopolamine-induced memory deficit.ResultsIn further phytochemistry study, a new hopan-type triterpenoid, (3β)-hopan-3-ol-28,22-olide (1), together with twenty known compounds were isolated (221). Compound 1, 2, 4, 5, 79, and 1113 exhibited potent acetylcholinesterase (AChE) inhibitory activity in a concentration-dependent manner with IC50 values ranging from 54.4 to 94.6 μM. Compound 13 was also shown anti-butyrylcholinesterase (BChE) activity with an IC50 value of 42.7 μM. The Morris water Y-maze, Y-maze, and object recognition test were also carried out.ConclusionsIt is noteworthy that MEXX is effective when administered orally to mice, experimental results are consistent with the traditional use of this medicinal plant species.
ABSTRACT
BackgroundAlzheimer’s disease (AD) is the most common cause of dementia among the elderly and is characterized by loss of memory and other cognitive functions. An increase in AChE (a key enzyme in the cholinergic nervous system) levels around β-amyloid plaques and neurofibrillary tangles is a common feature of AD neuropathology. Amnesic effects of scopolamine (acetylcholine receptor antagonist) can be investigated in various behavioral tests such as Morris water maze, object recognition, Y-maze, and passive avoidance. In the scope of this paper, we report the anti-AChE, anti-BChE properties of the isolated compound and the in vivo effects of the methanolic extract ofXylia xylocarpa (MEXX) on scopolamine-induced memory deficit.ResultsIn further phytochemistry study, a new hopan-type triterpenoid, (3β)-hopan-3-ol-28,22-olide (1), together with twenty known compounds were isolated (221). Compound 1, 2, 4, 5, 79, and 1113 exhibited potent acetylcholinesterase (AChE) inhibitory activity in a concentration-dependent manner with IC50 values ranging from 54.4 to 94.6 μM. Compound 13 was also shown anti-butyrylcholinesterase (BChE) activity with an IC50 value of 42.7 μM. The Morris water Y-maze, Y-maze, and object recognition test were also carried out.ConclusionsIt is noteworthy that MEXX is effective when administered orally to mice, experimental results are consistent with the traditional use of this medicinal plant species.
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