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 Determination of organic and inorganic compounds in the human body, who is living nearby Hoa Khanh industrial park, Central of Vietnam.
Tác giả hoặc Nhóm tác giả: Le Phuoc Cuong, Truong Van Thien, Le Thi Xuan Thuy, Gumerov Farid
Nơi đăng: International Journal of Advanced Research in Chemical Science; Số: Vol. 2 (9);Từ->đến trang: 41-51;Năm: 2015
Lĩnh vực: Môi trường; Loại: Bài báo khoa học; Thể loại: Quốc tế
Abstract: A combination of spectral and chromatographic analytical methods has been executed to monitor organic and inorganic compounds in the body of citizens, who is living nearby Hoa Khanh IP, central of Vietnam. Methods were developed for the determination of some chemical elements in hair by inductively coupled-plasma atomic emission spectroscopy with limits of detection reaching 1 - 100 μg L-1. A supercritical fluid extraction (SFE) and clean-up procedures were established for isolating organochlorine pollutants (OCPs) and organophosphorus pesticides (OPPs) from the hair of the test subjects. Eight OCPs and OPPs were determined by SFE with carbon dioxide only and methanol-modified carbon dioxide extraction at 350 bar and 45oC, followed by gas chromatography coupled to mass spectrometry. The results indicated that OCPs can be extracted quantitatively using CO2 only, whereas OPPs require a modifier for extraction. The limits of detection that were found were between 0.7 to 1.3 μg g-1, and good linearity (r2 > 0.9861) was achieved within the tested ranges. The activities of the N-acetyltransferase (NAT) and the monooxygenases cytochrome P450 (CYP 450) were determined and compared to the acetylation and oxidation phenotypes of healthy test subjects, who are living nearby Hoa Khanh IP from 1 to 10 years. The variations in the concentration of chemical elements in human hair were shown to be dependent upon the activities of the two-phase metabolic system, on the individual’s gender and the duration of residence within Hoa Khanh IP.
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